Yohanan Simon was born in 1905 in Berlin. He attended the Max Beckmann Art School in Frankfurt and the Academy of Fine Arts in Munich. Simon moved to Paris in 1927, where he attended the famed École des Beaux-Arts.
In 1934 Simon moved to New York where he worked for Vogue Magazine and in 1936 he immigrated to Palestine where he was a member of Kibbutz Gan Shmuel up until 1953.
Simon executed a number of murals for Israeli ships, public buildings and hotels, including Bank of Israel offices in New York and hotel on the Ivory Coast and illustrated books and designed stage-sets.
He Participated in the Venice Biennale twice in the years 1948 and 1958 and in the Sao Paolo Bienale in 1953.
Simon received the Dizengoff Prize for Painting and Sculpture four times in 1945, 1946, 1953 and 1961, in addition to the Ramat Gan Prize which he received in 1958 and the Histadrut Prize which he received in 1960.
Yohanan Simon died in 1976.